Table III.
Odds ratios for asthma, wheezing and medications at 5 and 7 years in each conception group, compared with ‘planned, normal TTC’ group.
| Group | Age 5 years |
Age 7 years |
||||
|---|---|---|---|---|---|---|
| n | Adjusted for sex only | Fully adjusted model | n | Adjusted for sex only | Fully adjusted model | |
| Asthma | ||||||
| Unplanned | 2039 | 1.42 (1.20, 1.67) | 1.11(0.94, 1.31) | 1827 | 1.30 (1.09, 1.54) | 0.96 (0.79, 1.16) |
| Mistimed | 3645 | 1.24 (1.08, 1.42) | 1.03(0.89, 1.19) | 3217 | 1.23 (1.07, 1.41) | 0.98 (0.84, 1.15) |
| Planned | 6575 | Comparison group | 5837 | Comparison group | ||
| All Subfertile | 782 | 1.28 (1.00, 1.65) | 1.39 (1.07, 1.80) | 704 | 1.22 (0.95, 1.57) | 1.23 (0.95, 1.59) |
| Untreated | 505 | 1.27 (0.94, 1.72) | 1.34 (0.98, 1.83) | 463 | 1.18 (0.86, 1.60 | 1.15 (0.84, 1.58) |
| OI | 173 | 0.88 (0.53, 1.46) | 0.96 (0.57, 1.61) | 154 | 1.10 (0.68, 1.78) | 1.17 (0.72, 1.90) |
| ART | 104 | 2.10 (1.16, 3.81) | 2.65 (1.48, 4.76) | 87 | 1.73 (0.97, 3.11) | 1.84 (1.03, 3.28) |
| Wheezing in the last year | ||||||
| Unplanned | 2039 | 1.33 (1.15, 1.55) | 1.13 (0.98, 1.30) | 1826 | 1.10 (0.91, 1.34) | 0.95 (0.77, 1.17) |
| Mistimed | 3645 | 1.21 (1.06, 1.38) | 1.08 (0.94, 1.24) | 3217 | 1.12 (0.95, 1.34) | 1.01 (0.84, 1.22) |
| Planned | 6575 | Comparison group | 5837 | Comparison group | ||
| All Subfertile | 782 | 1.23 (0.97, 1.57) | 1.27 (1.00, 1.63) | 704 | 1.15 (0.87, 1.51) | 1.08 (0.82, 1.43) |
| Untreated | 505 | 1.22 (0.93, 1.60) | 1.24 (0.94, 1.63) | 463 | 1.22 (0.88, 1.68) | 1.15 (0.83, 1.60) |
| OI | 173 | 0.97 (0.58, 1.60) | 1.00 (0.61, 1.66) | 154 | 0.66 (0.34, 1.28) | 0.64 (0.33, 1.22) |
| ART | 104 | 1.76 (1.00, 3.12) | 1.97 (1.10, 3.53) | 87 | 1.65 (0.85, 3.20) | 1.50 (0.77, 2.92) |
| Anti-asthmatic medications taken daily | ||||||
| Unplanned | 2039 | 1.59 (1.20, 2.10) | 1.34 (1.02, 1.78) | 1827 | 1.21 (0.92, 1.58) | 1.03 (0.76, 1.39) |
| Mistimed | 3645 | 1.18 (0.92, 1.51) | 1.04 (0.81, 1.34) | 3217 | 1.37 (1.07, 1.76) | 1.21 (0.95, 1.55) |
| Planned | 6575 | Comparison group | 5837 | Comparison group | ||
| All Subfertile | 782 | 1.87 (1.30, 2.70) | 1.90 (1.32, 2.74) | 704 | 1.67 (1.16, 2.42) | 1.63 (1.13, 2.34) |
| Untreated | 505 | 1.51 (0.94, 2.41) | 1.51 (0.94, 2.41) | 463 | 1.56 (1.00, 2.43) | 1.52 (0.97, 2.38) |
| OI | 173 | 1.65 (0.77, 3.51) | 1.65 (0.77, 3.55) | 154 | 1.57 (0.72, 3.44) | 1.57 (0.73, 3.41) |
| ART | 104 | 4.11 (1.96, 8.64) | 4.67 (2.20, 9.94) | 87 | 2.48 (1.05, 5.86) | 2.29 (1.00, 5.24) |
Odds ratios (95% confidence interval) presented for all subfertile, and by subgroup. Fully adjusted models, controlling for effects of confounding factors: Age 5: maternal history of asthma, family smoking, social class, maternal age; Age 7: maternal history of asthma, family smoking, family income, family type, siblings and pets in the home
Italics indicate subgroups within the ‘All subfertile’ category. The comparison group remains the ‘Planned, normal time to conception’ children.