Table II.
Leptin, total adiponectin, leptin to adiponectin ratio and risk of laparoscopically confirmed endometriosis in the NHS II blood cohort, stratified by BMI (kg/m2)a.
| BMI < 25 (n = 594) | BMI ≥ 25 (n = 446) | |
|---|---|---|
| Leptin (µg/ml) | ||
| Q1 (<9.7) | 1.0 (referent) | 1.0 (referent) |
| Q2 (9.7–16.5) | 1.2 (0.8–1.7) | 0.4 (0.1–2.2) |
| Q3 (16.6–30.6) | 1.2 (0.8–2.0) | 0.2 (0.1–1.4) |
| Q4 (≥30.7) | 1.3 (0.5–3.4) | 0.3 (0.1–1.7) |
| P-value, test for trend | 0.40 | 0.98 |
| P-value, test for heterogeneity | 0.47 | |
| Total adiponectin (µg/ml) | ||
| Q1 (<4.7) | 1.0 (referent) | 1.0 (referent) |
| Q2 (4.7–6.4) | 0.7 (0.4–1.2) | 0.9 (0.6–1.5) |
| Q3 (6.5–8.9) | 0.9 (0.5–1.5) | 1.3 (0.7–2.2) |
| Q4 (≥9.0) | 0.8 (0.5–1.4) | 0.6 (0.3–1.2) |
| P-value test for trend | 0.83 | 0.37 |
| P-value, test for heterogeneity | 0.62 | |
| Leptin to adiponectin ratio | ||
| Q1 (<0.17) | 1.0 (referent) | 1.0 (referent) |
| Q2 (0.17–0.41) | 2.0 (0.7–5.9) | 0.9 (0.6–1.4) |
| Q3 (0.42–0.86) | 1.6 (0.6–4.6) | 1.0 (0.5–1.9) |
| Q4 (≥0.87) | 1.2 (0.4–3.5) | 1.3 (0.4–3.8) |
| P-value test for trend | 0.08 | 0.75 |
| P-value, test for heterogeneity | 0.36 | |
aResults expressed as RRs and 95% CIs calculated using unconditional logistic regression models adjusting for age, race, infertility history, menopausal status at diagnosis, month and time of day of blood draw. Test for heterogeneity was assessed using the likelihood ratio test comparing the model with main effects only with the model with main effects and interaction terms.