Table 2.
Cytoplasmic CCNB2 staining, clinicopathological characteristics and univariate Cox Regression analysis in 80 invasive breast cancer patients
|
Cytoplasmic CCNB2 expression | ||||||
|---|---|---|---|---|---|---|
| Characteristics | Negative | Positive | P* | HR | 95% CI | P ¤ |
|
Age (years) |
|
|
0.79 |
1.5 |
0.8-2.9 |
0.2 |
| 27-50 |
6 (24) |
19 (76) |
|
|
|
|
| >50 |
13 (28) |
34 (72) |
|
|
|
|
|
Histologic type |
|
|
0.04 |
0.8 |
0.4-1.5 |
0.5 |
| Ductal |
17 (29) |
41 (71) |
|
|
|
|
| Lobular |
0 (0) |
8 (100) |
|
|
|
|
| Ductal + lobular |
1(100) |
0 (0) |
|
|
|
|
| Other |
0 (0) |
4 (100) |
|
|
|
|
|
Tumor size (mm) |
|
0.88 |
1.0 |
1.0-1.0 |
1.0 |
|
| pT1 (0–20) |
3 (25) |
9 (75) |
|
|
|
|
| pT2 (>20-50) |
14 (27) |
38 (73) |
|
|
|
|
| pT3 (>50) |
2 (25) |
6 (75) |
|
|
|
|
|
BRE grade |
|
|
0.99 |
1.1 |
0.8-1.5 |
0.5 |
| I-II |
10 (28) |
26 (72) |
|
|
|
|
| III |
9 (25 ) |
27 (75) |
|
|
|
|
|
Axillary lymph node status |
0.90 |
1.0 |
0.5-2.0 |
1.0 |
||
| Negative |
6 (25) |
18 (75) |
|
|
|
|
| Positive |
13 (27) |
35 (73) |
|
|
|
|
|
No. of axillary lymph nodes |
0.34 |
1.0 |
0.7-1.4 |
0.8 |
||
| 1-3 |
4 (19) |
17 (81) |
|
|
|
|
| ≥4 |
9 (33) |
18 (67) |
|
|
|
|
|
ER/PR status |
|
|
0.40 |
1.1 |
0.6-2.1 |
0.8 |
| Negative |
11 (32) |
23 (68) |
|
|
|
|
| Positive |
8 (21) |
30 (79) |
|
|
|
|
|
HER2/neu status |
0.9 |
0.7 |
0.3-1.5 |
0.4 |
||
| Positive |
7 (32) |
15 (68) |
|
|
|
|
| Negative |
10 (27) |
27 (73) |
|
|
|
|
|
ASPM |
|
|
0.03 |
0.9 |
0.5-20 |
0.9 |
| Negative |
10 (45) |
12 (55) |
|
|
|
|
| Positive |
24 (37) |
41 (63) |
|
|
|
|
|
KIAA0101 |
|
|
0.70 |
1.1 |
0.5-2.3 |
0.8 |
| Negative |
16 (48) |
17 (52) |
|
|
|
|
| Positive |
3 (8) |
36 (92) |
|
|
|
|
|
SLC27A2 |
|
|
0.08 |
0.6 |
0.3-1.3 |
0.2 |
| Negative |
11 (20) |
43 (80) |
|
|
|
|
| Positive |
8 (44) |
10 (56) |
|
|
|
|
| CCNB2 | 19 (26) | 53 (74) | 0.004 | 6.1 | 2.0-20 | 0.003 |
P-value determined by chi-square test. * P-value of the correlation between CCNB-2 expression and clinicopatholigical parameters. ¤ P-value of hazard ratio (HR). BRE, Bloom, Richardson, Elston/Ellis; CI, confidence interval. All parameters were coded as 0 (negative) and 1 (positive) except as noted. Pathologic tumor size was coded as 1 (0-20mm), 2 (>20-50mm) and 3 (>50mm). Histologic type was coded as 1 (ductal), 2 (lobular ductal), 3 (ductal and lobular) and 4 (other). (N) = No. of patients (%).