Skip to main content
. 2012 Dec 24;110(2):731–736. doi: 10.1073/pnas.1219733110

Fig. 2.

Fig. 2.

Local injection of CLR dsRNA decreases ileitis mediated by TxA. After 7 d of pretreatment with non-CLR dsRNA or CLR dsRNA, an ileal loop spanning the dsRNA injection site was infused with vehicle or TxA (5 µg). (A) After 4 h of treatment, intestinal secretion was determined as the weight/length (mg/cm) of the excised loop. Secretion was significantly decreased (P < 0.05) with CLR dsRNA pretreatment. (B) MPO activity was also decreased in loop fluid (U/L) after CLR dsRNA pretreatment. Values are mean ± SEM per loop, n = 4–12 loops per group. *P < 0.05 vs. vehicle, #P < 0.05 vs. rats pretreated with non-CLR dsRNA and injected with TxA.