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. 2012 Dec 24;110(2):731–736. doi: 10.1073/pnas.1219733110

Fig. 3.

Fig. 3.

Local injection of CLR dsRNA decreases histopathologic changes induced by TxA. A portion of loop tissue was sectioned and stained with hematoxylin and eosin. (A) Graphical representation of the histologic score is shown. Duplicate sections were scored for epithelial damage, edema and congestion, and neutrophil infiltration (0–5 per end point) (17). *P < 0.05 vs. vehicle, #P < 0.05 vs. rats treated with non-CLR dsRNA, followed by TxA treatment 7 d later. Values are mean ± SEM per loop, n = 8–12 loops per group. PMNs, polymorphonuclear leukocytes. (B) Pretreatment with CLR dsRNA minimized histopathologic indications of inflammation induced by TxA. In the non-CLR dsRNA controls, TxA induced severe damage (note dilated blood vessels; arrows). Pretreatment with CLR dsRNA preserved epithelial integrity even after TxA treatment (arrowheads). lp, lamina propria (n = 6–8 per group). (Scale bar, 100 µm.)