Fig. 4.

(A) Graph of the protein interaction network determined for the cPUFs of S. pneumoniae by microfluidic chip technology. Black and red nodes denote the cPUFs and proteins with functional annotation, respectively. Proteins in the dashed box are ribosome associated; the grey node is cPUF SP1748). All genes with annotations and interaction partners are given in detail in SI Materials and Methods. (B) The functional categories found for the cPUFs based on the majority rule and functional prediction.