Table 2.
Differences in CSF and serum cytokine levels between high and low cytokine responders at A, B and C
| Group | csf IL-2 | csf IL-4 | csf IL-5 | csf IL-8 | csf IL-10 | csf IL-12 | csf IL-13 | csf TNF | csf INFγ | serum IL-4 | serum IL-8 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A |
high responders |
|
|
|
|
|
|
|
|
|
19.30 (10) |
22.65 (10) |
| |
rest of sample |
|
|
|
|
|
|
|
|
|
16.00 (23) |
14.54 (23) |
| |
U,P-value |
n.s. |
n.s. |
n.s. |
|
n.s. |
|
|
|
|
92.00, 0.027* |
58.50, 0.027* |
|
B |
high responders |
22.80 (10) |
18.10 (10) |
19.70 (10) |
24.30 (10) |
22.70 (10) |
23.10 (10) |
19.50, 0.001 |
23.80 (10) |
21.50 (10) |
|
23.15 (10) |
| |
rest of sample |
13.64 (22) |
15.00 (21) |
14.24 (21) |
12.05 (21) |
12.81 (21) |
12.62 (21) |
11.76 (21) |
12.29 (22) |
14.23 (22) |
|
14.33 (23) |
| |
U,P-value |
47.00, 0.008** |
84.00, 0.037* |
68.00, 0.042* |
22.00, <0.001*** |
38.00, 0.005** |
34.00, <0.001*** |
16.00, <0.001*** |
27.00, 0.001*** |
60.00, 0.016* |
n.s. |
53.50, 0.016* |
|
C |
high responders |
24.00 (10) |
|
25.00 (10) |
25.15 (10) |
25.00 (10) |
23.35 (10) |
25.55 (10) |
|
20.65 (10) |
|
|
| |
rest of sample |
13.09 (22) |
|
12.64 (22) |
12.57 (22) |
12.64 (22) |
13.39 (22) |
12.39 (22) |
|
14.61 (22) |
|
|
| U,P-value | 35.00, 0.002* | n.s. | 25.00, <0.001*** | 23.50, <0.001*** | 25.00, 0.001*** | 41.50, 0.001*** | n.s. | 68.50, 0.027 | n.s. | n.s. |
Differences between groups based on ranks, with mean rank in cytokine levels and number of patients (n) in the different groups for each cytokine is presented, followed by Mann–Whitney U statistics U-values, P-values. The α-level was set to 0.005, *<0.05, ** <0.01, *** ≤0.001.