Table 3.
Associations between vitamin D status and bone and inflammation biomarkers (univariate analysis)
| |
|
All patients |
Severe 25-(OH) vitamin D3 deficiency (<10ng/ml) |
moderate 25-(OH) vitamin D3 deficiency (10–30 ng/ml) |
25-(OH) Vitamin D3 >30 ng/ml |
p value |
|---|---|---|---|---|---|---|
| N = 263 | N = 95 (36%) | N = 135 (51%) | N = 33 (13%) | |||
| Bone metabolism parameters |
Ionized calcium <1.12 mmols/l, n (%) |
9 (3%) |
3 (3%) |
3 (2%) |
3 (9%) |
0.001 |
| |
CTX (ng/mL), median (interquartile range) |
0.45 (0.30-0.77) |
0.49 (0.31-0.92) |
0.45 (0.31-0.70) |
0.33 (0.22-0.60) |
0.05 |
| |
High serum CTX, n (%) |
56 (21%) |
29 (32%) |
24 (18%) |
3 (9%) |
0.01 |
| |
Serum intact parathyroid hormone > 65 ng/l, n (%) |
62 (24%) |
31 (34%) |
29 (21%) |
2 (6%) |
<0.0001 |
| inflammation parameters |
hsCRP (mg/l), median (interquartile range) |
1.7 (0.7-4.0) |
2.3 (1.2-5.3) |
1.5 (0.9-2.7) |
1.4 (0.8-4.2) |
0.12 |
| IL6 (pg/ml), median (interquartile range) | 1.8 (1.0-3.6) | 2.0 (0.7-6.3) | 1.7 (0.6-3.6) | 1.6 (1.0-3.8) | 0.002 |
hsCRP: highly-sensitive C-Reactive Protein; IL6: Interleukin 6; High serum CTX = C Telopeptide X > 0.748 ng/ml (men), 0.738 ng/ml (pre-menopausal women), and 1.351 ng/ml (menopausal women).