Table 3.
Multivariable-adjusted odds ratios and 95% confidence intervals for pancreatic cancer by plasma adiponectin, among subgroups*
| No. of case subjects | No. of control subjects | Plasma adiponectin levels, µg/mL | |||
|---|---|---|---|---|---|
| Characteristic | <4.4 | ≥4.4 | P interaction | ||
| All participants | 468 | 1080 | 1.00 (referent) | 0.62 (0.47 to 0.82) | |
| Sex | |||||
| Men | 142 | 347 | 1.00 (referent) | 0.55 (0.35 to 0.86) | |
| Women | 326 | 733 | 1.00 (referent) | 0.65 (0.45 to 0.95) | .42 |
| Age at blood draw | |||||
| <63 y, median | 201 | 496 | 1.00 (referent) | 0.60 (0.40 to 0.91) | |
| ≥63 y | 267 | 584 | 1.00 (referent) | 0.64 (0.43 to 0.94) | .90 |
| Follow-up time of case subjects | |||||
| <5 y | 110 | 246 | 1.00 (referent) | 0.90 (0.48 to 1.68) | |
| 5–9 y | 176 | 387 | 1.00 (referent) | 0.42 (0.26 to 0.68) | |
| ≥10 y | 182 | 447 | 1.00 (referent) | 0.68 (0.44 to 1.05) | .66 |
| Fasting time | |||||
| <8 h | 104 | 255 | 1.00 (referent) | 0.48 (0.27 to 0.84) | |
| ≥8 h | 364 | 825 | 1.00 (referent) | 0.66 (0.48 to 0.92) | .57 |
| Smoking status | |||||
| Never | 195 | 471 | 1.00 (referent) | 0.51 (0.33 to 0.80) | |
| Past/current | 273 | 609 | 1.00 (referent) | 0.66 (0.46 to 0.95) | .57 |
| BMI | |||||
| <25kg/m2 | 211 | 518 | 1.00 (referent) | 0.61 (0.39 to 0.96) | |
| 25–29.9kg/m2 | 168 | 405 | 1.00 (referent) | 0.64 (0.40 to 1.02) | |
| ≥30kg/m2 | 89 | 157 | 1.00 (referent) | 0.57 (0.31 to 1.06) | .78 |
| Physical activity | |||||
| <6 MET-hr/wk, tertiles | 160 | 301 | 1.00 (referent) | 0.75 (0.43 to 1.31) | |
| 6–17.9 MET-hr/wk | 142 | 351 | 1.00 (referent) | 0.59 (0.35 to 1.00) | |
| ≥18 MET-hr/wk | 166 | 428 | 1.00 (referent) | 0.50 (0.32 to 0.78) | .11 |
| C-peptide levels | |||||
| < 1.4ng/mL, tertiles | 156 | 355 | 1.00 (referent) | 0.67 (0.35 to 1.27) | |
| 1.4–2.1ng/mL | 113 | 398 | 1.00 (referent) | 0.73 (0.42 to 1.26) | |
| ≥2.2ng/mL | 199 | 327 | 1.00 (referent) | 0.55 (0.37 to 0.83) | .21 |
* Odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for the matching factors including age (continuous), prospective cohort (Health Professionals Follow-up Study, Nurses’ Health Study, Physicians’ Health Study, Women’s Health Initiative, Women’s Health Study), smoking status (never, past, current), fasting time (0 to <4, 4 to <8, 8 to <12, ≥12 hours), and month of blood draw (2-month intervals), and other covariates in the multivariable model 3, including race (white, black, other), history of diabetes mellitus (yes, no), current multivitamin use (yes, no), plasma 25-hydroxyvitamin D levels (quartiles), body mass index (BMI) (<18.5, 18.5–24.9, 25–29.9, ≥30kg/m2), physical activity (quartiles), and plasma C-peptide levels (quartiles), excluding the stratification variable. All statistical tests were two-sided. MET, metabolic equivalent.