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Distribution of long interspersed nucleotide element 1 (LINE-1) methylation levels in 1224 colorectal cancer cases in the Nurses’ Health Study and the Health Professionals Follow-up Study. LINE-1 methylation level was determined by polymerase chain reaction on bisulfite-modified genomic DNA from archival paraffin-embedded tumor tissue, followed by pyrosequencing, as described in the Methods.
