Table 5. The summary of histopathological fibrosis score for the rat models by modified Hepatitis Activity Index (HAI) system.
DMN model (6th week) | CCl4 model (9th week) | |||||
Fibrosis score | Control n (%) | DMN n (%) | DMN+MGP n (%) | Control n (%) | CCl4 n (%) | CCl4+MGP n (%) |
0–1 | 18 (100) | 3 (19) | 12 (67) | 20 (100) | 7 (35) | 16 (80) |
2–3 | 0 (0) | 13 (81) | 6 (33) | 0 (0) | 13 (65) | 4 (20) |
Fibrosis was graded as (0–1) for observations ranging from normal tissue to fibrous expansion of portal tracts and (2–3) for bridge fibrosis to frequent bridging fibrosis with nodule formation. The number of rats was counted and used to calculate the percentage of each histopathological level at each time point.