Figure 6. Shr promotes GAS virulence in murine models of infection. (A) Separate cohorts of female CD-1 mice 10 weeks of age (n = 8) were subcutaneously challenged with non-lethal doses of WT 5448 or 5448Δshr (~1 × 107 CFU/100 μl) and lesion size monitored daily. The asterisks indicate values that are statistically significantly different (p < 0.05). (B) Shr is required for full virulence in a mouse model of systemic infection. CD-1 female mice (10 weeks of age; n = 8) were injected intraperitoneally with either WT 5448 or 5448Δshr (~4 × 106 CFU/200 μL PBS with 5% gastric mucin) and monitored twice daily for mortality (p < 0.0001).