Table 3.
Allelic and genotypic frequencies and risks for glioma in Chinese
| Genotyped SNPs | MAF | Common homozygote (n) | Heterozygote (n) | Rare homozygote (n) | Heterozygote and rare Homozygote (n) | P for trend | |
|---|---|---|---|---|---|---|---|
|
GPX1 promoter (rs1800668) |
Case |
0.12 |
301 |
66 |
13 |
79 |
|
| Control |
0.09 |
314 |
64 |
4 |
68 |
0.110 |
|
| OR (95% CI)* |
|
Reference |
1.05 (0.72-1.53) |
3.30 (1.07-10.24) |
1.18 (0.82-1.69) |
|
|
|
CAT 5’region (rs769214) |
Case |
0.28 |
198 |
146 |
32 |
178 |
|
| Control |
0.29 |
192 |
146 |
36 |
182 |
0.609 |
|
| OR (95% CI)* |
|
Reference |
0.93 (0.69- 1.26) |
0.83 (0.49- 1.39) |
0.91 (0.68- 1.21) |
|
|
|
CAT 5’region (rs7943316) |
Case |
0.33 |
180 |
140 |
53 |
193 |
|
| Control |
0.29 |
195 |
153 |
32 |
185 |
0.074 |
|
| OR (95% CI)* |
|
Reference |
1.04 (0.77- 1.41) |
1.16 (0.75- 1.79) |
1.19 (0.89- 1.58) |
|
|
|
PON1 3' UTR (rs854552) |
Case |
0.22 |
237 |
120 |
23 |
143 |
|
| Control |
0.23 |
231 |
126 |
24 |
150 |
0.653 |
|
| OR (95% CI)* |
|
Reference |
0.96 (0.70- 1.30) |
0.96 (0.53- 1.75) |
0.96 (0.71- 1.28) |
|
|
|
PON1 Q192R (rs662) |
Case |
0.35 |
161 |
158 |
52 |
210 |
|
| Control |
0.36 |
159 |
167 |
52 |
219 |
0.833 |
|
| OR (95% CI)* |
|
Reference |
0.98 (0.72- 1.34) |
1.06 (0.68- 1.65) |
1.00 (0.75- 1.33) |
|
|
|
NQO1 3' UTR (rs10517) |
Case |
0.39 |
142 |
170 |
60 |
230 |
|
| |
Control |
0.35 |
154 |
181 |
44 |
225 |
0.162 |
| |
OR (95% CI)* |
|
Reference |
0.99 (0.73- 1.35) |
1.44 (0.92- 2.26) |
1.08 (0.81- 1.45) |
|
|
NQO1 S1P (rs1800566) |
Case |
0.46 |
109 |
181 |
78 |
259 |
|
| Control |
0.47 |
108 |
187 |
86 |
273 |
0.610 |
|
| OR (95% CI)* |
|
Reference |
1.00 (0.71- 1.39) |
0.93 (0.62- 1.40) |
0.98 (0.71- 1.34) |
|
|
|
MnSOD V16A (rs4880) |
Case |
0.22 |
241 |
107 |
31 |
138 |
|
| Control |
0.12 |
293 |
81 |
6 |
87 |
<0.001 |
|
| OR (95% CI)* |
|
Reference |
1.55 (1.11- 2.16) |
6.05 (2.48- 14.74) |
1.86 (1.35- 2.55) |
|
|
|
MnSOD 3' UTR (rs5746136) |
Case |
0.51 |
95 |
182 |
100 |
282 |
|
| Control |
0.46 |
118 |
178 |
85 |
263 |
0.058 |
|
| |
OR (95% CI)* |
|
Reference |
1.17 (0.83- 1.64) |
1.34 (0.90- 1.99) |
1.22 (0.89- 1.68) |
|
|
SOD3 T58A (rs2536512) |
Case |
0.25 |
235 |
96 |
44 |
140 |
|
| Control |
0.11 |
283 |
73 |
25 |
98 |
<0.001 |
|
| OR (95% CI)* |
|
Reference |
1.51 (1.06- 2.14) |
2.01 (1.20- 3.39) |
1.64 (1.20- 2.23) |
|
|
|
SOD3 3' UTR (rs2695232) |
Case |
0.41 |
142 |
165 |
75 |
240 |
|
| Control |
0.41 |
134 |
172 |
70 |
242 |
0.922 |
|
| OR (95% CI)* |
|
Reference |
0.87 (0.63- 1.19) |
0.97 (0.65- 1.45) |
0.90 (0.67- 1.20) |
|
|
|
NOS1 3' UTR (rs2682826) |
Case |
0.25 |
209 |
104 |
23 |
127 |
|
| Control |
0.28 |
193 |
164 |
24 |
188 |
0.017 |
|
| OR (95% CI)* |
|
Reference |
0.57 (0.42- 0.79) |
0.87 (0.47- 1.59) |
0.61 (0.45- 0.82) |
|
|
|
NOS1 Q902H (rs1047735) |
Case |
0.46 |
123 |
165 |
90 |
255 |
|
| Control |
0.49 |
101 |
183 |
94 |
277 |
0.197 |
|
| OR (95% CI)* |
|
Reference |
0.80 (0.57- 1.11) |
0.85 (0.57- 1.25) |
0.81 (0.60- 1.11) |
|
|
|
NOS2 L608S (rs2297518) |
Case |
0.19 |
241 |
120 |
8 |
128 |
|
| Control |
0.17 |
255 |
113 |
9 |
122 |
0.584 |
|
| OR (95% CI)* |
|
Reference |
1.10 (0.80- 1.50) |
0.92 (0.35- 2.42) |
1.08 (0.80- 1.47) |
|
|
|
NOS2 promoter (rs10459953) |
Case |
0.40 |
140 |
178 |
64 |
242 |
|
| Control |
0.44 |
122 |
184 |
73 |
257 |
0.173 |
|
| OR (95% CI)* |
|
Reference |
0.88 (0.64- 1.21) |
0.80 (0.53- 1.21) |
0.86 (0.64- 1.16) |
|
|
| NOS3 D298E (rs1799983) | Case |
0.15 |
282 |
77 |
17 |
94 |
|
| Control |
0.12 |
278 |
84 |
15 |
99 |
0.856 |
|
| OR (95% CI)* | Reference | 0.91 (0.64- 1.29) | 1.12 (0.55- 2.29) | 0.94 (0.68- 1.30) |
*Multivariable adjustment by age, gender (male or female), smoking status (never, former or current), and pack-years.
Data in boldface represent P < 0.05.
MAF: Minor Allele frequency.