Table 4.

Joint effects of unfavorable genotypes in case patients and control subjects in Chinese

Risk group (no. unfavorable genotypes)	Cases	Controls	OR (95% CI)*
Reference groupa (n = 0)	147	205	Reference
Low-risk reference group (n = 1)	96	83	1.51 (1.05- 2.17)
Medium-risk group (n = 2)	108	76	1.86 (1.30-2.67)
High-risk group b (n ≥3)	11	3	4.86 (1.33-17.71)
P for trend			<0.001

*Adjusted for age, gender, smoking status, and pack-years.

^aReference group: GPX1 promoter: CC, MnSOD V16A: TT, SOD3 T58A: GG, and NOS1 3' UTR: CT+TT.

^bBecause the subject number in group ‘4’ was sparse (one control and three patients), the subjects with greater than three unfavourable genotypes were combined as the high-risk group.