Table 1.
Proteasome subunits
| Subunits | Structure and Function |
|---|---|
| Base sub-complex: | |
| Rpt1 | AAA+ domain subunit |
| Rpt2 | AAA+ domain subunit |
| Rpt6 | AAA+ domain subunit |
| Rpt3 | AAA+ domain subunit |
| Rpt4 | AAA+ domain subunit |
| Rpt5 | AAA+ domain subunit |
| Rpn1 | PC-repeat solenoid, binds Ubp6 and shuttle factors Rad23, Ddi1, and Dsk2 |
| Rpn2 | PC-repeat solenoid, binds Rpn13 |
| Rpn13 | Ubiquitin binding by Pru domain |
| Lid sub-complex: | |
| Rpn9 | PCI-domain subunit |
| Rpn5 | PCI-domain subunit |
| Rpn6 | PCI-domain subunit |
| Rpn7 | PCI-domain subunit |
| Rpn3 | PCI-domain subunit |
| Rpn12 | PCI-domain subunit |
| Rpn8 | Inactive Jab1/MPN domain |
| Rpn11 | Active Jab1/MPN domain with JAMM motif deubiquitination active site |
| Rpn10 | Ubiquitin binding by UIM, lid binding by VWA domain |
| Core Particle: | |
| α1–7 | gating subunits |
| β1–7 | β1, β2, β5 contain proteolytic active sites |