Table 1. Top 15 GO Functional Enrichment Analysis for the List of 165 Significantly Altered mRNAs.
(p < 0.05, B-H, FDR < 0.2). Cells shaded in gray represent a GO category that reached significance with p < 0.05 and a B-H corrections, however were unable to meet significance with an FDR of 20%.
| Category | Term | Term Description | Genes | Hit In List | Hit in Query | p-value | B-H | FDR 20% |
|---|---|---|---|---|---|---|---|---|
| Biological Process | GO:0019226 | transmission of nerve impulse | PLP1, EGR2, MAL, PRKCG, MBP, CD9, BDNF, ASPA, SLC17A6, SYN2, PLLP, UGT8, CORT, PMP22, DRD1A, CACNA1B | 16 | 283 | 1.11E-07 | 3.08E-05 | 1.83E-04 |
| Biological Process | GO:0042391 | regulation of membrane potential | CD9, PLP1, ASPA, BDNF, EGR2, PLLP, MAL, UGT8, PMP22, DRD1A, MBP | 11 | 153 | 2.56E-06 | 5.89E-04 | 0.004213 |
| Biological Process | GO:0051969 | regulation of transmission of nerve impulse | EGR1, TF, ARC, BDNF, EGR2, PTGS2, SYN2, CALB1, HTR2C, DRD1A, CACNA1B | 11 | 176 | 8.95E-06 | 0.001764 | 0.014721 |
| Biological Process | GO:0044057 | regulation of system process | EGR1, TF, ARC, EGR2, PTGS2, TACR3, HSPA1A, CALB1, BDNF, SSTR2, SYN2, DRD1A, HTR2C, CACNA1B | 14 | 319 | 1.49E-05 | 0.002564 | 0.024459 |
| Biological Process | GO:0006873 | cellular ion homeostasis | TF, PLP1, EGR2, WFS1, MAL, LPAR1, MBP, CD9, BDNF, ASPA, PLLP, UGT8, PMP22, DRD1A, CAR2 | 15 | 370 | 1.58E-05 | 0.002424 | 0.026015 |
| Biological Process | GO:0007610 | behavior | EGR1, EGR2, PTGS2, ENPP2, WFS1, CNP, PRKCG, NR4A3, CALB1, CXCL12, FOS, BDNF, CORT, DRD1A, HTR2C, CACNA1B | 16 | 424 | 1.71E-05 | 0.002144 | 0.02812 |
| Biological Process | GO:0010001 | glial cell differentiation | SOX10, PLP1, ASPA, EGR2, TSPAN2, GSN, DRD1A | 7 | 59 | 2.36E-05 | 0.0025 | 0.038756 |
| Biological Process | GO:0010033 | response to organic substance | EGR1, TF, IRS2, EGR2, TACR3, GATM, PTGS2, KLF10, COL3A1, HSPA1A, NR4A3, CXCL12, JUNB, DDR1, FOS, DUSP1, GSN, STEAP2, HTR2C, DRD1A, CRYM, CAR2, CACNA1B, DNAJB5 | 24 | 928 | 3.07E-05 | 0.003025 | 0.050514 |
| Biological Process | GO:0019725 | cellular homeostasis | TF, PLP1, EGR2, SLC12A2, WFS1, MAL, LPAR1, MBP, CD9, BDNF, ASPA, PLLP, UGT8, PMP22, DRD1A, CAR2 | 16 | 453 | 3.69E-05 | 0.003181 | 0.060708 |
| Biological Process | GO:0048167 | regulation of synaptic plasticity | EGR1, ARC, BDNF, EGR2, PTGS2, CALB1, DRD1A | 7 | 81 | 1.42E-04 | 0.010295 | 0.233931 |
| Cellular Component | GO:0005886 | plasma membrane | GYPC, PTGS2, TACR3, GNA12, TNFSF13, LPAR1, GPR88, CXCL12, VCL, MBP, S1PR5, SLC4A2, KCNG3, NT5E, ARC, IRS2, STXBP3, DDR1, SSTR2, NPTXR, CLIC4, COL1A2, VAMP1, PMP22, STEAP2, TF, APH1A, LITAF, KCNA1, HSPA1A, GJC2, FXYD6, CD9, CDC42EP2, CDC42EP1, SYN2, GPNMB, CAR2, MAG, PLP1, SLC12A2, MYO1D, NTNG1, MCAM, HOMER1, GJB1, ACCN1, SLC6A9, FNBP1, SLC17A6, P2RX6, GPR37, SCN4B, HTR2C, DRD1A, CACNA1B | 56 | 2396 | 4.70E-10 | 1.03E-07 | 5.98E-07 |
| Cellular Component | GO:0044459 | plasma membrane part | TF, TACR3, APH1A, PTGS2, LITAF, GNA12, KCNA1, HSPA1A, TNFSF13, GJC2, VCL, MBP, CD9, SYN2, SLC4A2, KCNG3, GPNMB, CAR2, PLP1, ARC, SLC12A2, MYO1D, NTNG1, STXBP3, HOMER1, GJB1, ACCN1, DDR1, FNBP1, SLC6A9, P2RX6, SLC17A6, SCN4B, VAMP1, PMP22, DRD1A, HTR2C, CACNA1B | 38 | 1358 | 1.80E-08 | 1.98E-06 | 2.29E-05 |
| Cellular Component | GO:0043209 | myelin sheath | MAG, PLP1, PLLP, PMP22, MBP | 5 | 15 | 1.43E-05 | 7.87E-04 | 0.01822 |
| Cellular Component | GO:0042995 | cell projection | S100A4, ARC, TACR3, WFS1, MYO1D, GNA12, FBXO2, PRKCG, HOMER1, MBP, NOV, ACCN1, P2RX6, CLIC4, GSN, DRD1A, NEFM, CAR2, CACNA1B | 19 | 727 | 5.30E-04 | 0.019237 | 0.672088 |
| Molecular Function | GO:0019911 | structural constituent of myelin sheath | PLP1, MOBP, TSPAN2, MAL, MBP | 5 | 5 | 3.24E-08 | 1.02E-05 | 4.36E-05 |