Table 2. Expression Pairing of miRNA-mRNA interactions.
miRNA expression analysis was carried out by identifying the miRNA species and their putative target mRNAs that were changed in the opposite direction. The target genes were run through DAVID gene ontology analysis; the colored boxes on the left represent an upregulated miRNA (red) and a down regulated miRNA (blue); the corresponding arrow in the next column on the left represents either upregulation (up arrow) or downregulation (down arrow) for the miRNAs, the arrow on the right in the same column represents either upregulation (up arrow) or downregulation (down arrow) for the mRNAs; the colored boxes on the right represent enriched gene ontology categories including (p > 0.05, B-H, FDR 20%): 1. Regulation of synaptic transmission; 2. Myelination 3. Regulation of synaptic plasticity 4. Neuron projection 5. Synaptic transmission 6. Plasma membrane 7. Cell-cell signaling 8. GPCR signaling 9. Axon guidance. Bold lettering represents PCR confirmed mRNAs and miRNAs. Refer to Supplemental Table 3 & 4 for p-values and fold change for each miRNA and mRNA displayed here.
| Gene Ontologies | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| miRNA | Expn Pairing | Gene Symbol | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
| rno-miR-106b-star |
|
Per2, Sstr2 | |||||||||
| rno-miR-125a-3p |
|
Accn1, Cxcl12, Fos, Nov, Sstr2, Syn2 | |||||||||
| rno-miR-151-star |
|
Cxcl12, Egr1, Junb | |||||||||
| rno-miR-18a |
|
Cxcl12, Gpr88, Gypc, Kcng3, Nr4a3, Tacr3 | |||||||||
| rno-miR-204-star |
|
Accn1, Egr4, Fos, Kcng3, Prkcg, Rgs12, Sstr2 | |||||||||
| rno-miR-206 |
|
Bdnf, Nr4a3 | |||||||||
| rno-miR-210 |
|
Bdnf, Cxcl12, Gypc, Nptxr | |||||||||
| rno-miR-218-star |
|
Bdnf, Calb1, Cxcl12, Nr4a1, Nr4a3 | |||||||||
| rno-miR-30c-2-star |
|
Arc, Cxcl12, Per2, Prkcg | |||||||||
| rno-miR-324-3p |
|
Arc, Cxcl12, Egr2, Klf10, Rgs12, Tacr3 | |||||||||
| rno-miR-351 |
|
Bdnf, Cacna1b, Syn2 | |||||||||
| rno-miR-378-star |
|
Egr2, Gpr88, Klf10 | |||||||||
| rno-miR-503 |
|
Bdnf, Cxcl12, Nr4a1 | |||||||||
| rno-miR-101a |
|
Plp1, Slc12a2, Slc17a6, Stxbp3, Tspan2, Ugt8 | |||||||||
| rno-miR-1O1b |
|
Cdc42ep2, Gpd1, Plp1, Slc12a2, Slc17a6, Stxbp3, Ugt8 | |||||||||
| rno-miR-137 |
|
Mbp, Mobp, Myo1d, Plp1, Scn1b, Slc12a2, Slc17a6, Tspan2, Vamp1 | |||||||||
| rno-miR-186 |
|
Aspa, Bcas1, Car2, Carhsp1, Cdc42ep2, Gjb1, Gpr37, Mobp, Ngb, Pbld, Plp1, Slc12a2, Tnfsf13, Tspan2 | |||||||||
| rno-miR-204 |
|
Aph1a, Lpar1, Mag, Nt5e, Plp1 | |||||||||
| rno-miR-218 |
|
Car2, Csrp2, Fermt2, Gpd1, Scn4b, Slc12a2 | |||||||||
| rno-miR-22-star |
|
Csrp1, Mog, Nrep, Olig1, Plp1, Ugt8, Vamp1 | |||||||||
| rno-miR-26b |
|
Bcas1, Lpar1, Plp1, Slc12a2, Ugt8, Vamp1 | |||||||||
| rno-miR-29c |
|
Carhsp1, Fermt2, Gpr37, Mobp, Mog, Myo1d, Nefm, Nt5e, P2rx6, Plp1, Pmp22, Scn4b | |||||||||
| rno-miR-301b |
|
Fermt2, Gpr37, Mid1ip1, Plp1, Slc17a6, Tspan2, Ugt8 | |||||||||
| rno-miR-340-5p |
|
Aph1a, Aspa, Fermt2, Mid1ipl, Myo1d, Plp1, Pmp22, S1pr5, Scn4b, Slc12a2 | |||||||||
| rno-miR-350 |
|
Aph1a, Bcas1, Car2, Carhsp1, Fermt2, Lpar1, Mid1ipl, Mobp, Nrep, Nt5e, Slc17a6, Slc6a9, Sox10, Ugt8 | |||||||||
| rno-miR-374 |
|
Aspa, Lpar1, Nt5e, Pllp, Stxbp3, Ugt8 | |||||||||
| rno-miR-376b-3p |
|
Cdr2, Fermt2, Mbp, Pmp22, Slc17a6 | |||||||||
| rno-miR-376b-5p |
|
Bcas1, Lass2, Lpar1, Slc17a6 | |||||||||
| rno-miR-376c |
|
Fermt2, Ngb, Nrep, Plp1, Pmp22, Sirt2, Stxbp3, Tnfsf13, Tspan2, Vamp1 | |||||||||
| rno-miR-382-star |
|
Aspa, Car2, Cdr2, Gpr37, Lpar1, Mettl7a, Mid1ip1, Plp1 | |||||||||
| rno-miR-466b |
|
Cnp, Gjb1, Gpd1, Lpar1, Mog, Pmp22, Slc17a6 | |||||||||
| rno-miR-7b |
|
Lpar1, Mal, Mettl7a, Plekhb1, Scn4b, Sox10, Tspan2 | |||||||||
| rno-miR-9 |
|
Cdr2, Gpnmb, Kcna1, Mettl7a, Mobp, Myo1d, Nefm, P2rx6, Pmp22, Vamp1 | |||||||||