Table 2.
Univariate analysis of effect of quality of HAPC’s in CM1 and CM2 and colon motility changes on decrease and discontinuation of ACE use
| ACE decrease* | ACE discontinuation | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Yes | No | p-value | Yes | No | p-value | |
| CM1 | ||||||
|
| ||||||
| HAPC normal | 3/25 (12) | 4/14 (29) | 0.24 | 2/11 (18) | 5/28 (18) | 0.94 |
|
| ||||||
| CM2 | ||||||
|
| ||||||
| HAPC normal | 14/25 (56) | 3/14 (21) | 0.02 | 6/11 (55) | 11/28 (39) | 0.34 |
|
| ||||||
| CM changes | ||||||
|
| ||||||
| GC improvement | 6/25 (24) | 5/14 (36) | 0.52 | 3/11 (27) | 8/28 (29) | 0.80 |
| HAPC improvement | 18/25 (72) | 5/14 (36) | 0.01 | 6/11 (55) | 17/28 (61) | 0.76 |
| HAPC normalizing | 12/25 (48) | 1/14 (7) | <0.01 | 5/11 (45) | 8/28 (29) | 0.28 |
| CM normalizing | 13/25 (52) | 1/14 (7) | <0.01 | 7/11 (64) | 9/28 (32) | 0.16 |
*
Includes those that discontinued ACE use. All values are expressed as proportion (%).
CM1, baseline colon manometry; CM2, repeat colon manometry; HAPC’s, high amplitude propagating contractions; GC, gastrocolonic response; ACEantegrade continence enemas