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Mean urinary estrogen metabolite (estrone conjugate [E1C]) concentration indexed by CR concentration before, 1 day after, and 2 days after hCG treatment in aging female macaques. A single dose (1,000 IU/animal) of hCG (NOVAREL) was administered intramuscularly 14 days after GnRHa treatment. CR, creatinine; GnRHa, gonadotropin-releasing hormone agonist; hCG, human chorionic gonadotropin.
