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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2012 Dec 11;21(3):618–631. doi: 10.1016/j.bmc.2012.11.050

Table 1.

Effect of substituent at R1 and R2 having 4-Methoxybenzyl at R3

graphic file with name nihms428062u4.jpg
Entry R1 R2 IC50 (μM)a
A549 Lung H460 Lung MCF-7 Breast MDA-MB-231 Breast OVCAR-3 Ovarian PC-3 Prostate
1 4-MeO-C6H4CH2 H 2.56 2.87 7.59 4.05 14.50 4.90
7a 4-MeO- C6H4CH2 CH3 NE NE NE NE NE NE
7b 4-MeO- C6H4CH2 CH2CH3 NE NE NE NE NE NE
8a 4-MeO- C6H4CH2 Ph NE NE NE NE NE NE
8b 4-MeO- C6H4CH2 4-CH3Ph NE NE NE NE NE NE
9a 4-MeO- C6H4CH2 (CH2)2COOH NE NE NE NE NE NE
9b 4-MeO- C6H4CH2 (CH2)3COOH NE NE NE NE NE NE
13a PhCH2 H NE NE NE NE NE NE
13b CH2CH3 H NE NE NE NE NE NE
13c 4-F- C6H4CH2 H 4.40 5.06 5.87 5.33 NE 7.67
a

NE - Not effective. Maximum dose did not inhibit the growth/proliferation by ≤ 75%