Table 2.

Hydrogen exchange predictions derived from the 3CI2 solution structure analysis

Model	Δlog kOH−	correlation	access in X-raya
1	2.32	0.58	8
2	2.57	−0.94	4
3	2.52	0.72	9
4	2.08	0.62	6
5	2.36	0.57	6
6	1.89	0.84	7
7	2.14	0.77	9
8	1.87	0.81	9
9	1.68	0.35	7
10	3.47	0.45	8
11	3.92	0.06	5
12	1.24	0.85	6
13	3.43	0.13	9
14	2.74	0.03	6
15	1.71	0.72	9
16	3.18	−0.20	7
17	1.63	0.69	6
18	2.74	0.72	8
19	3.60	0.38	9
20	3.87	0.22	6
ave	2.55	0.42	7.2

^aNumber of amide hydrogens exposed to solvent > 0.5 Ų that are similarly exposed in the CI2 X-ray structures (14 total).