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. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: Methods. 2012 Aug 8;58(4):349–359. doi: 10.1016/j.ymeth.2012.07.029

Fig. 4 — Heat maps representing interaction profiles obtained with HT-GPCA for E6 and E7 using the Gold-Standard (GS) dataset. Interaction matrix of E6 (A) or E7 (B) from 11 genotypes were tested with HT-GPCA against two reference sets of cellular proteins. Normalized Luminescence Ratio (NLR) as determined by HT-GPCA and ranging from strong to null interactions is displayed on a blue to light yellow scale. Each column displays the interaction profile for a single HPV genotype (top), with cellular targets corresponding to literature-curated interactions (LCI) designated by their HUGO Gene Symbol (left). The current knowledge area corresponding to LCI is delimited by red lines.

Fig. 4 — Heat maps representing interaction profiles obtained with HT-GPCA for E6 and E7 using the Gold-Standard (GS) dataset. Interaction matrix of E6 (A) or E7 (B) from 11 genotypes were tested with HT-GPCA against two reference sets of cellular proteins. Normalized Luminescence Ratio (NLR) as determined by HT-GPCA and ranging from strong to null interactions is displayed on a blue to light yellow scale. Each column displays the interaction profile for a single HPV genotype (top), with cellular targets corresponding to literature-curated interactions (LCI) designated by their HUGO Gene Symbol (left). The current knowledge area corresponding to LCI is delimited by red lines.