Somato-dendritic localization of voltage-gated sodium channels. (A) Immunofluorescence localization of the pan-Nav, Nav1.1, Nav1.2 and Nav1.6 subunits in the CA1 area. (B) Double immunofluorescence reaction shows weak pan-Nav immunolabeling along the Kv2.1 subunit immunoreactive somato-dendritic plasma membrane of CA1 PCs. Note the much higher labeling intensity of the AISs. slm: stratum lacunosum-moleculare, sr: stratum radiatum, sp: stratum pyramidale, so: stratum oriens; Scale bars: A, 100 μm; B, 10 μm.