Skip to main content
. Author manuscript; available in PMC: 2014 Jan 8.
Published in final edited form as: Cell Metab. 2013 Jan 8;17(1):20–33. doi: 10.1016/j.cmet.2012.11.012

Fig. 4. Activation of SHP-1 and inhibition of survival pathways in diabetes.

Fig. 4

Schematic illustration of mechanisms promoting apoptosis in retinal pericytes and glomerular podocytes. PDGF and VEGF receptor signaling promotes cell survival. In diabetes, activation of SHP-1 can dephosphorylate these receptors and contribute to apoptosis. Abbreviations: MAPK, mitogen-activated protein kinase; NFκB, nuclear factor κB; PDGF, platelet-derived growth factor; PDGFR, PDGF receptor; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; ROS, reactive oxygen species; SHP-1, Src homology-2 domain-containing phosphatase-1; VEGF, vascular endothelial growth factor; VEGFR2, VEGF receptor-2. Artwork by Leah A. Klein.