Table 1.
Numbers of SNPs genotyped and passing the inclusion criteria, among 46 candidate genes and two intergenic regions.
| Gene | Total tag SNPs | Tag SNPs passing inclusion criteria | Gene inclusion criteria | |||
|---|---|---|---|---|---|---|
| AHRR | 27 | 24 | ||||
| AIP/ARA9/XAP2 | 2 | 0 | ||||
| ARNT | 5 | 4 | Canonical AhR | |||
| AhR | 11 | 8 | ||||
| HSP90 | 6 | 4 | ||||
| p23/PTGES3 | 4 | 4 | ||||
| ARNTL | 19 | 14 | ||||
| CCNT1 | 3 | 3 | ||||
| DAP3 | 3 | 1 | ||||
| ESR1/ER-a | 49 | 33 | ||||
| GTF2F1 | 3 | 1 | ||||
| GTF2F2 | 9 | 6 | ||||
| HIF1A/MOP1 | 6 | 2 | ||||
| NCOA1/SRC1/RIP160 | 11 | 6 | ||||
| NCOA2/SRC2 | 19 | 14 | ||||
| NEDD8 | 4 | 4 | ||||
| NR2F1 | 2 | 2 | AhR interacting genes (Entrez Gene) | |||
| NRIP1/RIP140 | 10 | 8 | ||||
| RB1 | 4 | 4 | ||||
| RELA/NFKB3 | 4 | 2 | ||||
| SMARCA4 | 10 | 6 | ||||
| SP1 | 4 | 4 | ||||
| SRC | 14 | 10 | ||||
| TAF4 | 6 | 4 | ||||
| TAF6 | 6 | 4 | ||||
| TBP | 6 | 3 | ||||
| XPO1 | 5 | 5 | ||||
| AR | 2 | 0 | ||||
| CREB1 | 4 | 3 | ||||
| ERB/ESR2 | 16 | 12 | ||||
| GR/NR3C1 | 18 | 15 | ||||
| GSTCD | 5 | 5 | AhR interacting genes (STRING) | |||
| GSTM1 | 1 | 0 | ||||
| MYC | 6 | 5 | ||||
| PPARA | 16 | 11 | ||||
| RELB | 6 | 4 | ||||
| UGT1A5 | 16 | 10 | ||||
| CYP1A1 | 2 | 1 | ||||
| CYP1A2 | 2 | 1 | Dioxin-induced genes | |||
| CYP1B1 | 6 | 5 | ||||
| TP53 | 5 | 1 | ||||
| ARNT2 | 58 | 36 | Genes associated with reproductive outcomes: Sone and Yonemoto 2008 | |||
| CYP17A1 | 6 | 4 | ||||
| 9q31.2, region 1 | 12 | 10 | Genes associated with reproductive outcomes (GWAS studies): He et al. 2009; Ong et al. 2009; Perry et al. 2009; Sulem et al. 2009 | |||
| 9q31.2, region 2 | 14 | 11 | ||||
| LIN28b | 13 | 10 | ||||
| GPR54 | 3 | 2 | Genes associated with reproductive outcomes (puberty-related) | |||
| KISS1 | 8 | 4 | ||||
| Total | 480 | 337 | ||||
| GWAS, genome-wide association studies. See “Methods” for additional information on gene selection. | ||||||