Table 4.

Association of TEQ tertiles with both G2 and TV pubertal onset, among those with 0 vs. 1 or 2 minor alleles, for SNPs with gene–environment interaction FDR q < 0.2 for either G2 or TV.

Outcome and SNP	TEQ tertiles	0 minor alleles	1 or 2 minor alleles
		HR (95% CI)	HR (95% CI)
G2 pubertal onset
rs258747 (GR)
G2, p G×E = 0.0001a*	1	1 (Reference)	0.57 (0.39, 0.84)
	2	0.39 (0.25, 0.62)	0.52 (0.35, 0.79)
	3	0.31 (0.17, 0.55)	0.41 (0.25, 0.66)
rs1866388 (GR)
G2, p G×E = 0.0005a*	1	1 (Reference)	0.47 (0.33, 0.68)
	2	0.46 (0.32, 0.66)	0.54 (0.38, 0.79)
	3	0.36 (0.23, 0.57)	0.45 (0.28, 0.72)
rs12212176 (ESR1)
G2, p G×E = 0.0009a*	1	1 (Reference)	0.71 (0.47, 1.06)
	2	0.62 (0.45, 0.86)	0.76 (0.52, 1.11)
	3	0.50 (0.34, 0.74)	0.84 (0.52, 1.37)
TV pubertal onset
rs258747 (GR)
TV, p G×E = 0.04a	1	1 (Reference)	0.72 (0.49, 1.06)
	2	0.49 (0.31, 0.78)	0.69 (0.46, 1.04)
	3	0.44 (0.25, 0.79)	0.43 (0.26, 0.70)
rs1866388 (GR)
TV, p G×E = 0.12a	1	1 (Reference)	0.74 (0.51, 1.07)
	2	0.58 (0.40, 0.83)	0.82 (0.56, 1.19)
	3	0.50 (0.32, 0.79)	0.43 (0.27, 0.71)
rs12212176 (ESR1)
TV, p G×E = 0.28a	1	1 (Reference)	0.88 (0.59, 1.31)
	2	0.68 (0.49, 0.95)	0.88 (0.60, 1.29)
	3	0.56 (0.37, 0.85)	0.49 (0.29, 0.82)
Abbreviations: G×E, gene–environment interaction; HR, hazard ratio. aGene–environment p-values shown here were calculated in models with additive genotype coding (as shown in Table 3), not in the model with tertile indicators presented here. In each model the reference group consists of the boys in the lowest TEQ tertile and with 0 minor alleles. All models adjusted for lead and PCB serum concentration and diet (total calories, percent calories from protein, fat, and carbohydrate) at 8–9 years of age, and parental education. *FDR q < 0.2.