Table 3.
KEGG pathways inferred from predicted ES proteins
| Parent KEGG pathway | No. of ESPs | Top KEGG pathway in the category |
|---|---|---|
| Metabolism: | ||
| Carbohydrate metabolism | 296 | Citrate cycle (TCA cycle) |
| Lipid metabolism | 221 | Fatty acid metabolism |
| Amino acid metabolism | 217 | Valine, leucine and isoleucine degradation |
| Energy metabolism | 188 | Oxidative phosphorylation |
| Glycan biosynthesis and metabolism | 167 | N-Glycan biosynthesis |
| Nucleotide metabolism | 137 | Purine metabolism |
| Xenobiotics Biodegradation and Metabolism | 104 | Metabolism of xenobiotics by cytochrome P450, Drug metabolism - other enzymes |
| Metabolism of Cofactors and Vitamins | 95 | Riboflavin metabolism |
| Metabolism of other amino acids | 70 | Glutathione metabolism |
| Biosynthesis of other Secondary Metabolites | 38 | Isoquinoline alkaloid biosynthesis |
| Metabolism of Terpenoids and Polyketides | 29 | Terpenoid backbone biosynthesis, Limonene and pinene degradation |
| Genetic Information processing: | ||
| Folding, sorting and degradation | 446 | Protein processing in endoplasmic reticulum |
| Translation | 334 | RNA transport |
| Transcription | 176 | Spliceosome |
| Replication and repair | 72 | Nucleotide excision repair |
| Environmental information processing: | ||
| Signal transduction | 243 | MAPK signaling pathway |
| Signalling, molecules and interaction | 23 | Cell adhesion molecules (CAMs) |
| Membrane transport | 6 | ABC transporters |
| Cellular processes: | ||
| Transport and catabolism: | 436 | Lysosome |
| Cell Growth and Death | 208 | Cell cycle |
| Cell communication | 130 | Tight junction |
| Cell Motility | 35 | Regulation of actin cytoskeleton |
| Organismal systems: | ||
| Immune system | 291 | Antigen processing and presentation |
| Nervous System | 186 | Glutamatergic synapse |
| Endocrine system | 172 | Insulin signaling pathway |
| Digestive System | 80 | Pancreatic secretion |
| Circulatory System | 52 | Cardiac muscle contraction |
| Excretory System | 51 | Proximal tubule bicarbonate reclamation |
| Development | 47 | Axon guidance |
| Environmental Adaptation | 30 | Circadian rhythm - mammal |
| Sensory System | 15 | Phototransduction |
| Human Diseases: | ||
| Infectious Diseases | 522 | HTLV-I infection |
| Neurodegenerative Diseases | 417 | Alzheimer's disease |
| Cancers | 241 | Pathways in cancer (overview) |
| Cardiovascular Diseases | 55 | Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Immune Diseases | 44 | Rheumatoid arthritis |
| Endocrine and Metabolic Diseases | 19 | Type II diabetes mellitus |