TABLE 2.

Response to attitudinal questions regarding initial therapy for CLM

Question	Median response (1–5) or n (%)			IQR
In general, do you prefer immediate liver resection or neoadjuvant preoperative chemotherapy as the initial therapy for patients with CLEARLY RESECTABLE colon cancer liver metastasis?
	Liver resection	3	Neoadjuvant	1–4
In general, if you do recommend neoadjuvant therapy for CLEARLY RESECTABLE colon cancer liver metastasis do you prefer the administration of cytotoxic agents alone (i.e., oxaliplatin or irinotecan-based therapies) or cytotoxic agents plus a biologic agent (i.e., bevacizumab or cetuximab)?
	Cytotoxic alone	3	Cytotoxic + biologic	2–4
In general, if you do recommend neoadjuvant therapy for CLEARLY RESECTABLE colon cancer liver metastasis do you prefer to treat to “maximal response” or a short predetermined course (4–6 cycles)?
	Maximal response	5	Short course	4–5
In general, if you do recommend preoperative therapy for UNRESECTABLE BUT POTENTIALLY CONVERTIBLE colon cancer liver metastasis do you prefer the administration of cytotoxic agents alone (i.e., oxaliplatin or irinotecan-based therapies) or cytotoxic agents plus a biologic agent (i.e., bevacizumab or cetuximab)?
	Cytotoxic alone	5	Cytotoxic + biologic	3–5
In general, if you do recommend preoperative therapy for UNRESECTABLE BUT POTENTIALLY CONVERTIBLE colon cancer liver metastasis do you prefer to treat to “maximal response” or do you prefer to stop chemotherapy when the patient has been “converted” to being resectable?
	Maximal response	5	Converted	2–5
In general, how do each of the following factors affect your clinical impression regarding the likelihood that the colon cancer liver metastasis is CURABLE?
	Likely incurable		Likely curable
CLM size >5 cm		3		3–4
CEA >200 ng/ml		3		2–3
Bilateral/bilobar disease		3		2–3
CLM >4 in number		2		2–3
Hilar LN metastasis		2		1–2
Resectable extrahepatic disease		2		1–3
When a patient presents with SYNCHRONOUS disease with resectable liver metastasis and an ASYMPTOMATIC colon cancer primary tumor, your preferred INITIAL course of therapy is:
	Surgery first	2	Chemotherapy first	1–3
What do you consider “OPTIMAL” surgical therapy for patients with a solitary, small <3 cm colon cancer liver metastasis?
	Radiofrequency ablation	5	Liver resection	5–5
Do you consider surgical resection to be a potentially curative therapy for colon cancer liver metastasis?
	Yes	197 (99 %)
	No	2 (1 %)
Do you consider intraoperative ablation to be a potentially curative therapy for colon cancer liver metastasis?
	Yes	133 (67 %)
	No	66 (33 %)
Do you consider intra-arterial therapy (e.g., yttrium-90, TACE, TAE) to be a potentially curative therapy for colon cancer liver metastasis?
	Yes	19 (10 %)
	No	180 (90 %)

All responses on Likert scale from 1 to 5. Median responses indicated

N number of respondents, CLM colon cancer liver metastasis, IQR interquartile range, CEA carcinoembryonic antigen, LN lymph node