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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Brain Res Bull. 2011 Nov 28;88(1):3–12. doi: 10.1016/j.brainresbull.2011.11.017

Fig. 2.

Fig. 2

Alternatively spliced isoforms of APP. The APP gene contains 19 exons. Exon 13a is not included in brain isoforms. Exons 7 and 8 can be alternatively spliced to produce APP695, APP751, and APP770. APP751 and APP770 include exon 7 (orange), which encodes a Kunitz protease inhibitor (KPI) domain. APP770 also includes exon 8 (green), which encodes an OX-2 domain.