Table 1. Representative mouse models of AD.

This list is not comprehensive, but includes important prototypes, some commonly used models, and those that are available from repositories and thus are most easily available.

	Tg Line	Gene/Isoform	Mutation	Promoter	Plaques (mo)	Cognitive deficits (mo)	Vendor Number	Reference
*hAPP models*
	PDAPP	hAPP695<751,770¹	Ind	PDGF-B	6–9	6	n.a.	[27, 41, 49, 73, 110]
	J20	hAPP695<751,770¹	Swe, Ind	PDGF-B	6	4	JAX 006293	[114, 126]
	Tg2576	hAPP695	Swe	HamPrP	9	10	Taconic 1349	[5, 163, 177]
	APP23	hAPP751	Swe	Thy1	6 CAA: 12	3	n.a.	[21, 91]
	TgCRND8	hAPP695	Swe, Ind	HamPrP	3 CAA: 11	3	n.a.	[29, 79]
	TASD-41	hAPP751	Swe, Lon	Thy1	3 CAA: 7	6	n.a.	[140]
	R1.40	hAPP YAC²	Swe	hAPP	14–15	16–17	JAX 005300	[66, 93, 94]
*Aβ Models*
	BRI-Aβ42A	BRI-Aβ42	n.a.	MoPrP	3	?	JAX 007182	[106]
*hAPP/PS1 models*
	PSAPP (Tg2576 × PS1)	hAPP695 PSEN1	Swe M146L	HamPrP PDGF-B	6	4	n.a.	[4, 40, 67]
	APPswe/PS1ΔE9	m/hAPP695³ PSEN1	Swe ΔE9	MoPrP MoPrP	6	6	JAX 004462	[82, 83, 146]
	5XFAD	hAPP695 PSEN1	Swe, Lon, Flo M146L, L28V	Thy1 Thy1	2	6	JAX 008730	[89, 118, 122, 123]
	2xKI	m/hAPP³ PSEN1	Swe P264L	mAPP mPS1	6	9–12	n.a.	[25, 184]
*Models with hTau*
	TAPP (Tg2576 × JNPL3)	hAPP695 hTau-4R0N	Swe P301L	HamPrP MoPrP	8–15	motor deficits	Taconic 2469	[100]
	3xTg	hAPP695 hTau-4R0N PSEN1	Swe P301L M146V	Thy1 Thy1 mPS1	6	4.5	JAX 004807	[12, 120, 121]
	htau	hTau PAC⁴	Wild-type	hTau	–	12	JAX 005491	[3, 44, 128]

APP minigene expressing all three isoforms, mostly KPI-positive APPs.

Yeast artificial chromosome, expressing entire human APP gene, including all isoforms.

Humanized mouse APP, in which three amino acids in Aβ are changed to the human sequence.

⁴

P1 artificial chromosome, expressing entire human tau gene, including all isoforms (H1 haplotype).