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. Author manuscript; available in PMC: 2013 Jan 16.
Published in final edited form as: Immunol Rev. 2008 Apr;222:180–191. doi: 10.1111/j.1600-065X.2008.00608.x

Fig. 3. T-cell dysfunction induced by arginase I.

Fig. 3

Tumor cells expressing COX-2 and releasing PGE2 induce the expression of arginase I and CAT-2B in MDSC. This expression leads to a reduction of extracellular levels of l-Arg, which activates GCN2 and inhibits the expression of CD3ζ, cyclin D3, and cdk4 through post-transcriptional and translational mechanisms.