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. Author manuscript; available in PMC: 2014 Feb 15.
Published in final edited form as: Behav Brain Res. 2012 Nov 5;239:139–147. doi: 10.1016/j.bbr.2012.10.046

Figure 6.

Figure 6

Repeated MA increases acetylation at histone H3K14 in the ventral and dorsal striatum. Mice were treated with either NaB 630 mg/kg or Veh, 30 min prior to MA 2 mg/kg or saline (Acq Tmt) for 10 days, then received two injections of saline on two consecutive days. Finally, all groups except controls (Sal) were administered MA 2 mg/kg on day 13 (Test Drug). Tissue was perfused 30 min after the final Sal or MA treatment and stained for acetylation at histone H3K14 and H4K12. A. Shown are optical density data (mean ± SEM from 3 averaged samples per individual), reflecting acetylation of H3K14 for the ventral and dorsal striatum. * p<0.05 for the difference between the indicated repeated MA treatment group (Veh + MA, MA 2 mg/kg) and control group (Veh + Sal, Sal). B. Shown are optical density data (mean ± SEM from 3 averaged samples per individual), reflecting acetylation of H4K12 for the ventral and dorsal striatum.