A, increased VASP phosphorylation and time-dependent decrease in nuclear β-catenin levels in HT-29 cells treated with SBA. B, decreased β-catenin–regulated protein, survivin after 10 μmol/L treatment with SBA. C, caspase-3 cleavage and PDE5 expression in HT-29 cells treated with 10 μmol/L SBA. D, Wnt/β-catenin signaling reporter activity in HCT 116 cells treated with SBA for 24 hours. E, suppression of β-catenin by 8-BrcGMP (100 μmol/L) in HCT 116 cells. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.