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. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Cancer Prev Res (Phila). 2012 May 3;5(6):822–833. doi: 10.1158/1940-6207.CAPR-11-0559

Table 1.

Potency of SS and SBA to inhibit cAMP and cGMP hydrolysis by PDE isozymes

		SBA sensitivity		SS sensitivity
PDE family	Substrate	cGMP IC₅₀, μmol/L	cAMP IC₅₀, μmol/L	cGMP IC₅₀, μmol/L	cAMP IC₅₀, μmol/L
1A	cAMP/cGMP	>100	>100	>100	>100
1B	cAMP/cGMP	>100	>100	>100	>100
1C	cAMP/cGMP	>100	>100	>100	>100
2A	cAMP/cGMP	>100	>100	97	>100
3A	cAMP/cGMP	>100	>100	84	>100
3B	cAMP/cGMP	>100	>100	>100	>100
4B	cAMP	ND	75	ND	>100
5A	cGMP	9	ND	38	ND
6C	cGMP	>100	ND	>100	ND
7A	cAMP	ND	>100	ND	>100
8A	cAMP	ND	>100	ND	>100
9A	cGMP	>100	ND	>100	ND
10A	cAMP/cGMP	62	77	70	>100
11A	cAMP/cGMP	>100	>100	>100	>100

Abbreviation: ND, not determined.