Fig. 6.

Eticlopride pretreatment does not attenuate the METH-induced decrease in VMAT-2M-associated vesicles as assessed 1 h after METH treatment. Rats received four injections of METH (7.5 mg/kg/injection, s.c., 2-h intervals) or saline vehicle (1 ml/kg/injection, s.c., 2-h intervals) and were killed 1 h later. Thirty minutes before each injection, rats were pretreated with eticlopride (ETIC; 0.5 mg/kg/injection, i.p.) or saline vehicle (1 ml/kg/injection, i.p.). Columns represent the mean ± 1 S.E.M. of 10 to 12 independent determinations. *, indicates a statistical difference from saline/saline treated animals.