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. 2012 Dec 30;2012:450838. doi: 10.1155/2012/450838

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Copyright © 2012 Won Kyung Jeon et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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F. mume improves spatial memory impairment induced by chronic BCCAo. (a) Search error measure of spatial learning during five trial sessions of training trials. Compared to the learning in sham-operated control rats (sham + vehicle), learning was significantly impaired in the BCCAo rats (BCCAo + Vehicle). F. mume (BCCAo + F. mume 200 mg/kg) treatment significantly ameliorated the learning impairment induced by chronic BCCAo. (b) The percentage of time spent in the target annulus (5× of the platform size). In both probe trials, sham-operated control rats showed spatial bias, whereas the BCCAo rats did not (*). Compared to the BCCAo rats, F. mume treatment (BCCAo + F. mume 200) significantly showed spatial bias in the first probe trial (#).