Fig. 9.
Heme was reduced in FDXR knockdown in HCT116 (K562) cells. Heme levels were significantly reduced (9A), by knockdown of FDXR protein (9B) and mRNA levels (9C), but ferrochelatase mRNA levels were increased (9C). In western blots, IRP2 levels increased, TfR1 increased, but ALAS2 protein levels decreased (9D).
