Table 1.

Summary of transgenerational mice studies.

Diets		Model	Study Design	Route of Administration	Endpoint Measurements	Authors
High Fat Diet	Chow (12% fat, 65% carbohydrate, 23% protein) vs. High fat (59% fat, 20% carbohydrate, 21% protein)	Wistar rats	Male and female rats were kept on a chow or high fat diet for 4 weeks and bred. Respective diets were continued throughout pregnancy and stopped at lactation. At 21 days, all pups were weaned onto a chow diet. Male offsprings were studied at 3 months of age.	Ad libitum	Body composition, glucose tolerance, insulin sensitivity, respiratory quotient, insulin receptor expression	Buckley, A.J. et al. [30]
	Chow (12% fat, 28% protein, 60% carbohydrate) vs. High fat (34% CHO, 45% fat, 20% casein)	C57BL/6: 129 hybrid	Female mice on chow or high-fat diet were bred to produce F1 offsprings. F1 offsprings on each diet were then bred to create four combination of F2 mice: F2 never exposed to high-fat diet from both maternal or paternal sources (chow), F2 mice exposed to high fat diet from paternal sources, F2 mice exposed to high fat diet from maternal source and F2 mice exposed to high fat diet both from paternal and maternal sources.	Ad libitum	Body composition, glucose tolerance, insulin sensitivity, serum insulin levels	Dunn, G.A. et al. [31]
	Chow ( 13% fat) vs. High fat (35% fat)	Japanese macaques	Animals were naturally bred over four seasons. Pregnancies were terminated by Cesarean at gestational day 130.	Not available	Liver histone acetylation, HDAC activity, liver gene expression	Aagaard-Tillery, K.M. et al. [33]
High Glycemic Diet	Not available	ICR mice	Pregnant ICR female mice divided into two groups: control and intrauterine hyperglycemia group with gestational hyperglycemia (GDM). Mice in the GDM group were injected with streptozotocin at a concentration of 150 mg/kg body weight. F1 control and GDM mice were then crossed to create 4 different F2 progeny: male and female F1 control mice, GDM F1 male and F1 female control mice, GDM F1 female mice and F1 male control mice, and male and female GDM F1 mice.	Not available	Glucose tolerance test, insulin tolerance test, insulin secretion, pancreas gene expression, DNA methylation	Ding, G.L. et al. [35]