Figure 5.

Effects of BAY11-7082 on OCM1 xenograft tumor growth in nude mice. The OCM1 xenograft nude mouse model was established as described in Materials and Methods. Tumor volumes were monitored before treatment. At the end of the experiments, tumor-bearing mice were sacrificed and the tumors were weighed after being separated from the surrounding muscles and dermis. (A) The graph represents tumor volumes in mice from the control and BAY11-7082 treated groups. (B) Representative images of tumors derived from mice in both groups. (C) Tumor weight of mice from the control and BAY11-7082 treated groups. (D) Representative images of TUNEL stained apoptotic cells derived from mice in both groups (200× magnification). E. Histograms demonstrated the numbers of apoptotic cells per visual field in tumor sections from both groups. (*p < 0.05, **p < 0.01).