Figure 1.

Schematic structure of RORα and interaction of RORα with other proteins andpathways. (A) RORα shows a typical domain structure with four major functional domains. The A/B region refers to amino-terminal of RORα. The C region, highly conserved among the ROR family members, is the DNA binding domain (DBD). D is the hinge domain and links the C region to the E region. The E region is the ligand binding domain (LBD); (B) Canonical (red) and non-canonical (blue) nuclear receptor activities that may contribute to tumor suppressor function of RORα.