Table 1.

Evidence and role of Sox family transcriptional factors in lung cancer.

Sox genes	Evidence or role in lung cancer
Sox1	Autoantibody to Sox1 detected in the serum of patients with SCLC [67,77–79].
Sox2	Autoimmunity found in patients with SCLC [64,67,78,79]; strongly expressed in both of NSCLC and SCLC tumor cells determined by IHC and/or FISH assays [62,63,66,76]; overexpression leads to lung cancer with poor prognostic outcome [48,80]; gene mutation(s) observed in SCLC [66]; inhibition of expression in cancer stem cells suppress the growth and metastasis of lung cancer [69].
Sox3	Autoantibody detected in patients with SCLC [67,78,79]; gene mutation(s) observed in SCLC [66].
Sox4	Autoantibody detected in the serum of patients with SCLC [81]; strong expression detected in SCLC tumor cells by IHC [61]; gene mutations found in SCLC and might be correlated with the lung cancerogenesis and tumor metastasis [18,65,66,82].
Sox5	Gene mutation (s) determined in SCLC [66]
Sox6	Gene mutation (s) observed in SCLC [66]
Sox7	Downregulation was correlated with a poor prognosis in patients with lung AC [47].
Sox9	Overexpression promoted lung adenocarcinoma cell proliferation [46]; gene mutation(s) detected in SCLC [66].
Sox11	Gene mutation (s) found in SCLC [66]
Sox14	Gene mutation (s) observed in SCLC [66]
Sox17	Gene mutation (s) detected in SCLC [66]
Sox18	Heterogeneous methylation was found in the promoter of gene [60].
Sox21	Autoantibody detected in the serum of patients with SCLC [67,78,79]