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. 2012 Dec 5;13(12):16598–16623. doi: 10.3390/ijms131216598

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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The “I-switch” DNA nanomachine recapitulates its pH-sensing properties in vivo. (A) the structure and working of an I-switch; (B) I-switch uptake in coelomocytes postinjection in C. elegans; (C) Stages in endosomal maturation of receptor-mediated endocytosis of a ligand; (D) donor channel, acceptor channel and respective pseudocolor D/A images of wild-type coelomocytes labeled with I-switch and clamped at pH 5 and 7. Scale bar, 10 ìm; (E) pH calibration curve of I-switch in vivo (red trace) and in vitro (black trace) showing normalized D/A ratios versus pH. Error bars indicate s.e.m. (n = 25 cells, ≥50 endosomes). Figures reproduced with permission from Macmillan Publishers [79].