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Expression of the MDR1 (A) and MRP3 (B) resistance gene in A-549, A-427 and NODO cell lines. Figures show quantification of gene expression by real time PCR. Cells were exposed to plasma concentrations of Pac, Car and Pac-Car at 8 h, 24 h, 48 h and 72 h (a, b, c and d, respectively). Parental cells without drug exposure were assessed as controls. Values are means ± SD of four separate experiments.
