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. 2012 Dec 7;13(12):16751–16768. doi: 10.3390/ijms131216751

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

The interrelationship between methylenetetrahydrofolate reductase (MTHFR) genotype, riboflavin and folic acid with respect to (a) cytosine-phosphate-guanosine dinucleotide (CpG) methylation and uracil in DNA; (b) initiation of cancer caused by CpG hypomethylation. The level of riboflavin and folic acid depends on supplementation [3], modified.