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. 2012 Dec 17;13(12):17230–17243. doi: 10.3390/ijms131217230

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Functional distribution of proteins among unique proteins of the rER and sER using Gene Ontology (GO) annotation with the hypergeometric test. (A) C57 control mice livers; (B) db/db mice livers. Unique proteins showing that the expression levels are higher at least 1.5-fold in each fraction were used for analysis (for C57 rER, 214 proteins; C57 sER, 166 proteins; db/db rER 148 proteins; db/db sER, 121 proteins). Proteins showing that the expression is higher or lower at least 5-fold are considered as exclusively expressed proteins in the indicated fraction. The degree of enrichment or depletion of identified proteins in a given function category is represented as −log(p).