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. 2001 Jun 26;98(14):8065–8070. doi: 10.1073/pnas.131214798

Figure 1.

Figure 1

A model of SNARE coil domain mediated inhibition of norepinephrine (NE) release from PC12 cells. SNARE monomers located at a fusion site after vesicle docking undergo two conformational changes leading to membrane fusion. The first (reaction 1) is the formation of a loosely associated trans SNARE complex. The second (reaction 2) is a zippering of the trans SNARE complex that leads to fusion. The monomers are the substrates for binding of the SNARE coil domain inhibitors (reaction 3). The complex formed by reaction 3 does not lead to a fusion event and thus blocks exocytosis. The SNAP-25 loop has been omitted for simplicity.