Skip to main content
. 2012 Oct 31;304(2):C180–C193. doi: 10.1152/ajpcell.00101.2012

Fig. 2.

Fig. 2.

Schematic representation of the regulation of PFK-1 as modeled in each model configuration. Model configuration i (A) represented the hypothesis in which no regulation of PFK-1 by calcium-calmodulin signaling is present. Model configuration ii (B) represented the hypothesis in which binding of calcium-calmodulin complexes to PFK-1 partly reliefs ATP inhibition of the enzyme independent of the levels of ADP and AMP. Model configuration iii (C) represented the hypothesis in which binding of calcium-calmodulin complexes partly reliefs ATP inhibition by enhancing the competititve binding of AMP and ADP to the inhibitory ATP site.