Table 1.
Maximal stress and 10-min stress induced by KPSS, 5 μM CCh, or 1 μM PDBu
| Tissue | KPSS |
5 μM CCh |
1 μM PDBu |
||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Maximal stress | 10-min stress | n | Maximal stress | 10-min stress | n | Maximal stress | 30-min stress | |
| Ileum | |||||||||
| SMB(+/+) | 12 | 20.5 ± 2.2 | 7.8 ± 1.2 | 7 | 17.4 ± 2.4 | 5.6 ± 0.9 | 6 | 7.6 ± 1.1 | 2.3 ± 0.5 |
| SMB(−/−) | 12 | 27.0 ± 3.9 | 14.7 ± 2.8 | 7 | 22.9 ± 3.6 | 9.5 ± 1.6 | 7 | 8.2 ± 1.9 | 3.3 ± 0.8 |
| P value | 0.16 | 0.03* | 0.23 | 0.06 | 0.79 | 0.34 | |||
| Antrum | |||||||||
| SMB(+/+) | 10 | 14.6 ± 1.5 | 3.0 ± 0.2 | 6 | 7.5 ± 2.2 | 1.6 ± 0.3 | 5 | 2.1 ± 0.6 | 0.3 ± 0.1 |
| SMB(−/−) | 10 | 17.3 ± 3.0 | 5.4 ± 1.1 | 5 | 13.2 ± 4.3 | 2.9 ± 1.5 | 5 | 1.4 ± 0.3 | 0.2 ± 0.1 |
| P value | 0.42 | 0.04* | 0.24 | 0.37 | 0.31 | 0.51 | |||
| Fundus | |||||||||
| SMB(+/+) | 11 | 22.0 ± 2.0 | 10.3 ± 1.3 | 6 | 20.2 ± 3.3 | 7.9 ± 1.6 | 6 | N/A† | 4.3 ± 0.6 |
| SMB(−/−) | 11 | 21.8 ± 2.6 | 9.3 ± 1.5 | 5 | 20.3 ± 4.0 | 8.8 ± 2.0 | 5 | N/A† | 3.7 ± 1 |
| P value | 0.95 | 0.64 | 0.98 | 0.72 | N/A† | 0.61 | |||
Values are mean ± SE. Stress unit is mN/cm2. KPSS, physiological saline solution; CCh, carbachol; PDBu, phorbol dibutyrate; SM, smooth muscle; N/A, not applicable,
*
Significant at P < 0.05.
†
No initial rapidly developed maximal stress for fundus induced by 1 μM PDBu.