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. 2012 Aug 8;32(32):11109–11119. doi: 10.1523/JNEUROSCI.0895-12.2012

Figure 3.

Figure 3.

MB decreases neurodegeneration and aggregation in a Drosophila model of HD expressing Httex1Q93. A, Drosophila were fed MB beginning at the larval (n = 5) or adult (n = 5) stage and analyzed for the number of rhabdomeres per omatidium. MB treatment beginning at the larval stage resulted in an increase in rhabdomeres per omatidium (Student's t test, ***p = 0.0005). The adult fed flied did not exhibit a rescue in neurodegeneration (Student's t test, p = 0.591). B, Treating Drosophila at the larval stage (n = 4) resulted in a decrease in the average number of aggregates (Student's t test, **p = 0.005). C, Treating at the larval stage (n = 4) also resulted in decreased size of the aggregates (Student's t test, *p = 0.03). Error bars represent group means ± SEM. D, Representative photomicrographs of eye antennal imaginal discs (larval) immunolabeled with anti-Htt (S830, green) and anti-elav (red) used for quantitation of aggregate number and size.