Figure 4.

Location of E4BP4 (E, in green), and XFD1 (X, in red), sites in non-coding DNA within zebrafish appb and surrounding 50 kb DNA. The green and red vertical lines above or below the horizontal line indicate sites in the forward and reverse strand of DNA, respectively. The short yellow vertical bars indicate exons of appb. Stars mark the E4BP4 and XFD1 sites shown to specifically bind the DNA-binding domains of zebrafish E4BP4 or Forkhead proteins respectively, by EMSA. The bent arrow indicates transcription start site of appb gene.